Here’s an informative video created by Gábor (LordOfMice) showing you how you can play Assassin’s Creed: Syndicate using Alt Controller and Hot Virtual Keyboard. You can download his Alt Controller profile and virtual keyboard layout from the links in the video description on YouTube, as well as find out more about Gábor and his amazing creative work.
Required: Mouse cursor, Left-click, two arrow keys, Hot Virtual Keyboard software.
The two arrow keys are controlled by switches in the video linked below. Mouse buttons could be used instead.